Any way a preamp can drive small speakers?

Preamps by themselves don't have the current to drive low impedance loads nor the output voltage to drive high impedance loads. If another driver (gain) stage is added, it can be done - then it would be called an integrated amp :)

Yes, if it has a headphone jack. Headphones are small speakers.

I have a McIntosh C34V pre which I bought new (and it still looks and sounds the same as day 1) which has a built in 20W/ch amp. While designed for headphones, Mac included speaker terminals on the rear of the pre. A nice, handy little touch.

Thanks for all responses!
I know this query is kind of off-the-wall but thought it would be interesting.
If you've ever seen the guts of a BAT 50SE preamp, you'll know why driving tiny speakers shouldn't be unreasonable.

I went to a Threshold demo many years ago and the rep had hooked up a Threshold FET 10e to small speakers to demonstrate the robustness of their separate power supply.
This particular preamp had a very low output impedance and put out a few watts of class A power into the speaker load at 8 ohms instead of the typical amp loak of 50 k ohms.