I've had good success starting with either "thirds" (speakers placed one third of the room length, seating at two thirds) or the Cardas ratios for placement. Then use complex acoustic music with good soundstaging (orchestral or large ensemble jazz) to spend time listening and moving the speakers and the listening position. Once an apparently optimal location is found that provides smooth even frequency response (which is what all those ratios are about), I then work on finetuning lateral spacing and toe-in. Marking the speaker location(s) with masking tape before repositioning is a big help in keeping track of the positioning experiments.
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