You should keep the speakers as small as possible and add a sub later only if needed.
I use OHM 100s and Dynaudio monitors in two 12X12 rooms in my house.
The largely omni OHMS work best. They are small footprint full range floorstanders. Being largely omnidirectional, they tend to fill teh room with sound rather than blast it at you, which is of benefit in a small room. They are also less fussy about location for smooth response than box designs in a square room.
OHM Micro Walsh Talls have an even smaller footprint than the 100s and are recommended for nearfield listening conditions as you will have in a room that size.
They can be auditioned in-house for several months. You really have nothing to loose.
www.ohmspeakers.com for more info.