Top 5 Hamburgers

Agree with Brent's. Super great hand cut lox.

Best Sandwiches:
Italian: NYC: Bar Stuzzichini, Defontes, Porchetta, Terroir, Torrisi
Chicago: Birchwood Kitchen, Joe Bostons
SF: Cane Rosso, Ironside, Orson, Sandbox Bakery, The Refuge
LA: Phillipes, Santa Fe Importers, Langers, Bay City, Claros, D' Elia's (Best bread ever)
LV: Snacks
Philly: Chinks, Dalessandros, Jim's Steaks, John's Roast Pork
New Orleans: Domilise's, Mothers

Thanks Tvad. I've been hearing about Langers for years; but it kind of fell off my radar. I'll get there the next time I'm in town, for sure.
I used to live across the street from Cal St. Northridge on Nordhoff, and I've never heard of Brent's. I'll give it a try also.
Bongo, you just flat out get around!
I enjoyed a place in Vegas the last time I was there. It's a small chain. It's called Hash House A Go Go. Take a look at the images Google puts up. It's lot of fun. San Diego's got one also. The dish I had was the featured dish on Man Versus Food.

Bongo,

I grew up in Chicago, and I have never been to Joe Boston's, but I will check it out when I am up there during the holidays.

For Chicago I-talian beef in Chi-town, we go done to Taylor Street area, Al's Italian Beef. Very tasty!!

Also, if you are downtown, I love Vesuvio (it's a great little very old Trattoria) near Navy Pier. It's still has authentic wise-guys hanging out there. Tells you how good it is!!