Top 5 Hamburgers

Best Sandwiches:
Italian: NYC: Bar Stuzzichini, Defontes, Porchetta, Terroir, Torrisi
Chicago: Birchwood Kitchen, Joe Bostons
SF: Cane Rosso, Ironside, Orson, Sandbox Bakery, The Refuge
LA: Phillipes, Santa Fe Importers, Langers, Bay City, Claros, D' Elia's (Best bread ever)
LV: Snacks
Philly: Chinks, Dalessandros, Jim's Steaks, John's Roast Pork
New Orleans: Domilise's, Mothers

Thanks Tvad. I've been hearing about Langers for years; but it kind of fell off my radar. I'll get there the next time I'm in town, for sure.
I used to live across the street from Cal St. Northridge on Nordhoff, and I've never heard of Brent's. I'll give it a try also.
Bongo, you just flat out get around!
I enjoyed a place in Vegas the last time I was there. It's a small chain. It's called Hash House A Go Go. Take a look at the images Google puts up. It's lot of fun. San Diego's got one also. The dish I had was the featured dish on Man Versus Food.

Bongo,

I grew up in Chicago, and I have never been to Joe Boston's, but I will check it out when I am up there during the holidays.

For Chicago I-talian beef in Chi-town, we go done to Taylor Street area, Al's Italian Beef. Very tasty!!

Also, if you are downtown, I love Vesuvio (it's a great little very old Trattoria) near Navy Pier. It's still has authentic wise-guys hanging out there. Tells you how good it is!!

Azaud: 4 million air miles. Everyone in my family thought Up In The Air was my life story.

Macdad,

Taylor Street isn't quite Taylor Street anymore and unfortunately, Al's has fallen victim to its own success, IMO.