Going from a multi strand silver cable to a single, solid core copper cable of high purity might be the way to go. It's been my (limited) experience that even well made multi strand cables impart a lush and pleasing midrange with a lessening of the tone, texture and detail in the lower bass. You can't have it all. Accentuate one aspect of the frequency and other parts can, and will suffer. Balance is the key.
Single, solid core cables seem to do the least harm to the signal and the end result might be what you're looking for.
Also, what lowrider57 says is true. I'd even go so far as to say that the serious coin should be spent on the ICs and once you have that dialed in, the speaker cables would be easier to sort out, provided that you're ICs are up to snuff.
All the best,
Nonoise