I seriously doubt that 0.45% change is audible. However, a general rule of thumb is that an amp with a DF of 20 or below has sonic consequences. Doing the math, the speaker in this case is 95% of the load -- a considerable change that results in sonic degradation from dynamic load variation since the amplifer is no longer a perfect voltage source .The 'traditional' thinking here is that frequency response is the last word on tonality.
It isn't.
It turns out that the human ear/brain system assigns a value to distortions; they are translated to tonality. In fact it now appears that there is a tipping point wherein colorations created by distortion can be favored over actual frequency response errors.
In addition, the use of global negative feedback is well-known to contribute to higher ordered harmonics (see Norman Crowhurst). The higher ordered harmonics are used by the ear/brain system to detect volume levels (rather than the fundamental tones). The result of trace amounts of higher ordered harmonics is called brightness and harshness because of human sensitivity to these harmonics.
This is why many designers don't use feedback and frequently favor tubes- to avoid that particularly annoying coloration. This often results in a high output impedance/low damping factor but this can be easily dealt with giving careful speaker selection.