Abnerjack,
In the case of Magnepans specifically, I think there is a good chance of both making a discernible difference in that my understanding is the fuse is actually directly in the signal path which is not the case with most electronics.
Which would make more of a difference of course like always depends on the details. What are you starting with and what are you going to and what are the differences. I suspect that comparison would be easier with the wires but assuming one actually knows what the technical differences are between two fuses, in teh case of Magnepan speakers its quite possible that a fuse change might make a bigger difference. Of course it all depends. In lieu of facts to base a decision on, one might as well just choose randomly what to try first and go from there.
The devil is always in the details.
I still am at a loss regarding how fuse direction matters so I cannot offer anything more there than most which is if you think it might matter try both ways and see.
A poster on another thread said he considered cables and interconnects as another component in his system. Do you kind people agree with that sentiment and do you consider fuses to be as significant?
Obviously they are parts of teh overall system as are the room, people listening, resistors, capacitors, and any other smaller part that makes up the larger.
The question is always what happens when you change anything and how much does it matter?
Myself, I have spent considerable time to-date dabbling with wires hearing differences and using them to fine tune my sound. There is a payoff there I believe in many cases. I have not experienced that yet with fuses but others clearly state they have. I have compared fuses in one case when asked and could not say for sure if I heard any difference consistently. My system sounds just the way I want it to currently so I have no plans to dabble with fuses again soon. There is still a few power cords for my amplifiers that I might consider playing with if time and money permits but what I have performs well and sounds great so no rush.