erik_squires
As far as I know, a 220V line is not an option for residential use in the US. Erik may have meant to suggest 240V, but you'll absolutely want to check with local officials before considering that - I think it may be against code in some locations. If you want to install isolation xformers, one option is to keep them out of the room and install them at or near the service panel.
Honestly the normally recommended sizes is best. Having too low an impedance will encourage more noise going back and forth in the wires ... To get uber-fancy run a 220V 60 AMP line and dedicate 220->120 V transformers in the room.Using "recommended sizes," or using the minimum gauge to meet code, is often not the best approach. By de-rating the wire, you'll reduce or eliminate voltage drop and improve the quality of your ground connection. That can yield greatly improved results. Using minimum wire gauge as a way to reduce noise is introducing a remedy that may be as bad or worse than the disease.
As far as I know, a 220V line is not an option for residential use in the US. Erik may have meant to suggest 240V, but you'll absolutely want to check with local officials before considering that - I think it may be against code in some locations. If you want to install isolation xformers, one option is to keep them out of the room and install them at or near the service panel.