What possible financial motive would Audioquest have in promoting cable and wire directionality?Cables can be built in such a way that they can be directional. The classic from of this is of course an interconnect with XLR terminations. It can only be plugged in one way.
But RCA cables can be built so that the shield is only tied at one end. Often this type of cable can express a directionality depending on how well the equipment in the system is grounded.
So there is a very practical reason for Audioquest to promote such a thing; hard to say if its financial but that is your speculation not mine.
Now let's entertain for a moment that raw wire and fuses are directional. Let's further say that you put them all in the same orientation in the equipment. The result would be high distortion, as the wire and fuse(s) would act like a diode, and thus rectify the audio signal. This is one way in which fuzzboxes (an electric guitar effect pedal) operate. Fuzzboxes are called that because of the sort of distortion they make.
As you can see, in the right hands a fuzzbox can really be a nice effect:
https://www.youtube.com/watch?v=JgqVHQITciY
But it does not work for hifi even though it sounds cool on a guitar. Its exactly the opposite of hifi: Distortion!
Now let's instead put all the wire and fuses in such a way that they are not all creating one series diode. In this case, the signal will still get rectified, only in a variety of different ways. This too will cause distortion.
Its pretty clear that most audiophiles would like to (and do) avoid that phenomena. To that end, non-directional wire and fuses should be sought out! If you have the pesky kind that is directional, count on it to add distortion to whatever signal is flowing through it.