'The end of science' bit in the title is mostly journalistic license in designing a hook for the article.
Nelson speaks on some of this via:
Nelson speaks on some of this via:
The other fundamental thing—number 2—is that I am centrally aware that all this is just entertainment, mine and yours. The objective needs of amplifier users are largely solved on a practical level, and as [Marshall] McLuhan perceptively noted, when that happens, we turn our technology into art. For me, the art lies in making simple, unusual amplifiers that sound great and measure fairly well. They aren't for everyone, but if they appeal to even a narrow segment of audiophiles, I'm perfectly happy. I'm equally happy if they are reliable.Thus not quite the end of science but an established science can head into being used in or as - art as commentary.
Read more at https://www.stereophile.com/content/nelson-pass-circuit-topology-and-end-science#T473FqLttf7wgh1I.99