The best tube compliment/combination will vary based on the mode of operation.
If single ended from input to single ended output, you only need to concern yourself with tube positions #1 and #2.
If you are running single ended inputs to balanced output, you need to concern yourself with tube position #1, 2, 4 and 5
If you are running balanced inputs to single ended output, you need to concern yourself with tube positions #1,2,3,6
Balanced in to Balanced output you need to concern yourself with tube positions #1,2,3,4,5,and 6
Tube positions 7 and 8 are for the headphones.
If single ended from input to single ended output, you only need to concern yourself with tube positions #1 and #2.
If you are running single ended inputs to balanced output, you need to concern yourself with tube position #1, 2, 4 and 5
If you are running balanced inputs to single ended output, you need to concern yourself with tube positions #1,2,3,6
Balanced in to Balanced output you need to concern yourself with tube positions #1,2,3,4,5,and 6
Tube positions 7 and 8 are for the headphones.