If they perform like other omnis I have heard, they probably sound best with some distance from walls in larger rooms.
I went to OHM Walsh omni's specifically for performance and flexibility in an assymetrical room (L shaped). Asymetrical rooms can be very problematic for most any kind of speaker, but I would tend to go for omnis if possible in these rooms.
My rational is that with an asymmetrical room you need speakers that adapt into the room and utilize it well as is, not speakers that sound best only once you've tweaked the room to optimize them which will never happen in an asymmetrical room.