Depends on a lot of things, how difficult your speakers are, where they are difficult, and how solid the power supply of the amplifier driving it is.
There's one major benefit to using bi-amping however, and that is the ability to use a DSP eq on just the bass section. This allows you to get most of the benefits of a dedicated/room corrected subwoofer, without having extra hardware between your speaker and DAC for the mid-treble regions.
Best,
E