Hi Sailfishben,
Well, I have never personaly experienced two subwoofers setup receiveing separate stereo signals. But I've heard from people who say it makes a big difference.
I figured I'd buy couple of subwoofers to try it out and A/B test it w/ a single subwoofer, and then sell the extra subwoofer if there is no significant difference.
As for actually hooking up cables, my McIntosh C45 preamp is perfect. For stereo inputs, it can simultaneously provide THREE (two XLR balanced, one unbalanced) outputs. I connect the preamp to my amp via XLR connection and will use the other L & R XLR outputs for the subwoofers.