putting a system together for your wifes Doctor? Why? I wouldn't unless she was paying me, personally!
But still, in the fairness to the question, my technical answer is that there's not enough variables and system/room specifics from you here to accurately suggest equipment!!!!
Medium sized basement?--What specific size and ceiling height? How many seats in the setup? How far sitting from screen? What's the lifestyle here?--music and movies both, or just movies? Acoustic treatments in the room? Bare walls? Moving around the house/room listening to music? Listening preferences?
One thing I'd not recommend is ANY Onkyo receiver, pesonally! So many other better receicer option,IMO-if you have to go receiver, at least. Harmon Kardon, Denon, Arcam, upper tier Yamaha's, Outlaw.-yada, yada
Anywhoz, I'd like to know more about the room, setup, and lifestyle, personally