uberwaltz,
Your question is like "how do you know magnetic bracelets don't work in healing people don't work if you haven't tried it?"
Just as a magnetic bracelet is based on medical claims that have no main-stream medical backing and the "evidence" is of the unreliable personal anecdote variety, it's the same with audiophile fuses.
As far as I know...and I'm happy to be corrected...the claim that introducing an audiophile grade fues in place of (a competently implemented) existing fuse in a component will alter the sound doesn't have backing by electrical engineers. Certainly I've seen electrical engineers - the ones who don't have an investment in selling audiophile fuses - saying it's nonsense.
Further, my skepticism is based both on my own experience, and in understanding the reasoning for why the scientific method exists.
I am well aware how fallible human perception is - there's a ton of science showing this. And my own blind tests have given me personal acquaintance with just how easy it is to think I perceive a sonic difference that isn't really there.
If there are measurements showing the output of a competently designed component actually changes with the introduction of an audiophile fuse...I'm not aware of it. But I'd appreciate a link if you have one.
But the talk of "200 hour break in" of a fuse is, I'm sorry, tin-foil-hat territory. And the method the OP used to determine the amazing sonic effects of these fuses is indistinguishable from those used to determine coloring or demagtezing CDs, or little resonating discs, "change" the sound, which electrical engineers (who aren't trying to sell these products) will explain as nonsense.