ozzy,
I would try either on your main power panel, or underneath a front end component (CD Player/Transport). You should hear significant improvements within the first 24 hours, but two weeks will show you what it is really capable of. You may experience some temporary break-in anomalies in the bass and treble during the two weeks.
I hit two weeks yesterday, and that wonderful relaxed quality has really come into bloom today. The difference between yesterday and today is readily apparent, and quite remarkable.
As far as the Bybees (and other similar tweaks) it would be good to remove them, just so your results are not skewed by any negative interaction.