I do not think it would be that difficult at all to design a randomized, double blinded study for audiophiles. I'm not saying it wouldn't be a little complex but it wouldn't be hard.It's fairly easy to design such a test, but it is a real challenge to actually conduct such a test if you want it to be scientifically valid. It's a tedious and laborious undertaking on the parts of all, including the test subjects.
The issue is who would need such a test and why. I do not think it is useful for an individual audiophile for whom the only determinant is "what do I like better".Agreed!