One of the main guys at Auralic, Xuanqian, indicates that he never turns off his device (or put it on standby). He just sets the screen as auto off and leaves it always on. Their devices do not have a true standby since it doesn't actually reduce power consumption. So they just call it sleep. I follow his lead and leave my Auralic Vega always on with screen set to auto off.
I also have Node 2 that I never power down.