I have a very similar system. Mac C46 pre, Mac mc501 mono blocks , JL audio C1 (really nice device) and a pair of JL audio E112 subs. I have 4 dedicated 20 amp circuits in my audio room and I have a noisy power source (I am on the Philadelphia pa power grid). I can tell you without any reservation that proper use of power conditioning and power cords makes a very big difference. I use a shunyata conditioner for pre-amp, Cr1 crossover and a Bryston DAC with very good results. High current amps are another matter. I plug them directly into wall outlets with shunyata Defenders in spare sockets. I have also been swapping power cords in and out of my system and have found amps most effected. High current cords are necessary to allow the amps to “breath”. The subs have seem not to be as sensitive to power souce and cable. This maybe due to the nature of the built in amps.
good luck
good luck