Is this size ok for the Kharma 1.0?
Dunno, sorry, always listened to it in large rooms. Mind you, they are big so you’ll need to treat the room & engage in super-careful placement!
Is there any bass?
Sufficient, I would say. I listen to classical and I could hear some of the cellos
I will be driving it with a BAT VK-500.
Sounds good, more than adequate
are these a fatiguing speaker?
No, not AFAI remember. They have a hard ceramic mid, however, that will screech on bad recordings