While I don’t really have an explanation, it hardly seems possible to me that minuscule traces of impurities that might be found in 6 nines copper can be responsible for the rather impressive changes to the sound when reversing cables. This was also the point made by HiFi Tuning in their results of a thorough evaluation of audiophile fuses, which appears on the Data Sheets on the HiFi Tuning website.
What HiFi Tuning says, in effect, is the relatively small measured differences in voltage drop for the fuses under evaluation, don’t completely explain the relatively large differences experienced in listening tests. [In fact, the measured differences were much smaller than HiFi Tuning states (5%) on the Data Sheets, by almost AN ORDER OF MAGNITUDE. Hel-loo!] So, I hereby declare considerable mystery still surrounds the whole directionality thing. Fortunately, all the world loves a mystery, right? 😛