For starters, at least a foot or two from rear wall and at least a foot or so from sides, with speakers generally farther apart than distance from listening position, but this can vary. Make sure tweeters are pointing forward towards the center of the room, in general crossing in front of prime listening position.
For 5s with adjustments, I recommend starting off towards lower settings for room size and bass/position relative to walls, then tweak from there as needed to get the best blend of soundstage and imaging and bass levels. Moving out from rear walls in general will improve imaging but will also affect bass levels. Small differences in actual location can make a big difference. Experiment until tuned in optimally.
For 5s with adjustments, I recommend starting off towards lower settings for room size and bass/position relative to walls, then tweak from there as needed to get the best blend of soundstage and imaging and bass levels. Moving out from rear walls in general will improve imaging but will also affect bass levels. Small differences in actual location can make a big difference. Experiment until tuned in optimally.