Eh hem!...Subwoofers... What do ya know?

toe in helps keep reflections off the side walls . Improves clairity and stage. Dont toe in so far that they aim in front of you . Most you want is at you .
my mains i set up with a building lazer. Centered , same angle and 40” from tweeter to rear wall . My focus point 20ft behind me . I dont have side reflection because my side walls are also 20ft away . My small living room is normal and my speakers aim directly at me. No sub required. 

gochurchgo, here are some starting point guidlines for a speaker placement and a youtube for the Crawl Test subwoofer placement. Since not every room has four corners, mapping out your rooms bass modes (where bass is louder) can be very usefull. 

http://www.cardas.com/room_setup_main.php

https://www.youtube.com/watch?v=AV3oLLMgS-M

Not every speaker system was designed to be toed in.

Subwoofers are a poor attempt in 2 channel listening.  If your speakers do not put out a decent bass response then it is what it is.  Subwoofer integration should be left for Home Theatre enthusiasts looking for bombs going off in their listening spaces.  I have tried sub integration and as a Bass player it does no justice.  Buy a speaker that produces a proper bass responce there are enough out there.

Further.......it puzzles me why individuals buy speakers with poor bass response...

I am quite fond of my ENTEC SW-1.