Does raising speaker cables off the floor really make a big difference?

I suppose it depends on the room, flooring material, cable length, cable covering,  cable weight and perhaps many more variables.  I suppose room humidity also plays a role.  Easy for us to have differing experiences with this lifting tweak. 

@andy2 --

As a matter of curiosity, would you be humbling if you didn’t see any difference?

Not sure I follow what you’re after, but I was merely using an example in a presumably related field to show my willingness to accept an effect of cable risers - easy they may be to ridicule. We’re chasing sonic bliss sometimes throwing thousands of dollars after hardware, only to find out that cheap accessories can have a bigger impact. By that I’m not saying hardware upgrades can’t be justified, only that other areas concerning their optimization can have a significant say as well.

If, hypothesized, I didn’t experience any pronounced difference in sound using the Ringmat domes I probably wouldn’t have posted..

So if one decides to go with cable risers, how long is the break-in period?

how long is the break-in period?

Theoretically, the break-in process is open-ended that is the cables continue to break-in as if "infinitely", that is again theoretically.  Practically, though it depends on one's system and one's hearing.  

So if one decides to go with cable risers, how long is the break-in period?

Good one..