USB cable: One Continuous length for Best SQ?


Relative digital newbie here.....In audiophile, digital music applications, does it matter if one splits up a long run of USB 2 connection between computer and DAC into separate attic/wall space lengths and shorter lengths which would connect to wall USB outlets?  Ideally, I’d like to connect my Mac (in a bedroom) to a DAC (connected to the living room audio system....looking at possibly a Schiit Bifrost 2 or similar price range).  I’m assuming this would require the use of step up devices along the path as I’m allowing for between 50-60’ cable between computer and DAC?  Would this impact sound quality?   Currently using my Mac > aging Airport Express in conjunction w/iTunes and the “Remote” app & no external DAC....Not interested in going with a different wireless streamer setup at this point.  Thanks!
lg1
@djones51,
I would be interested in hearing how it works for you.
I am in need of running a signal from my main rig to my office-about 50 feet of wire. So, the options are USB w/booster, Optical, or SPDIF, or Ethernet.
I was thinking of using the USB+repeater/booster, but am thinking that running ethernet for the long run and then converting to USB near the second system might be a better solution.
Bob
I never tried it, I was just showing the OP a solution for very little money he could try. I use ethernet for long runs. 
Long USB cable run will not work as mentioned by other Gon posters. Please check the Sonore OpticalRendu optical/USB converter. This will not only solve your USB cable issue, but will provide galvanic isolation upstream of your router. You would be surprised on the level of noise present coming from your network. I was so impressed by the black background when I installed it. You may need to install a fiber media converter (FMC) between your router and OpticalModule if you do not have an available SFP slot on your router.

https://audiophilestyle.com/forums/topic/55217-sonore-opticalrendu/