What your choice speakers with spikes or speakers with a vibration isolation device?

The best choice would depend upon the speakers used, the floor/substructure composition and (of course) your ears/preference.

List your gear/room/floor info in order to receive informed/meaningful opinions.

DeKay 

Delay,

‘’Tekton 4-10 subs (2) Onboard amps
‘Tekton  Moab  Speakers Mcintosh/caerver 275 bi amped
macintosh, mx122 pre, mb50 DAC,mpc1500 power, mac 1706 amp for surrounded speakers , Mac mvp 871 cd dvd, pine tree cabling thru-out

carpet over 3/4’ plywood on wood joist
room size 18 x 24. 8 ceiling 

Interesting cables (never heard of them, but just went through their site).

Your listening room is approx. the same dimensions as mine (though probably better as it's a rectangle instead of the odd horseshoe I have).

Assume that bass it full/deep as it has been in my room with previous fuller range speakers (than my current tiny Tots:-).

My first thought would be to isolate the subs from the sprung floor, while in turn simply spiking the speakers to the same (Tekton supplies spikes I gather).

Forget the name of the fave sub isolation platforms (not expensive as I recall) and perhaps another member can fill in the blank.

Think the manufacturer may also offer isolation stands for small desktop monitors.

DeKay

Anyone using IsoAcoustics Gaia feet under their speakers?
If on carpet are you also using their spikes that couple with their feet?
Results?   Thanks!

Anyone using IsoAcoustics Gaia feet under their speakers?
If on carpet are you also using their spikes that couple with their feet?
Results?   Thanks!