Absolutely. Notice my system
https://systems.audiogon.com/systems/8367 There's a 12" isobaric Talon Roc sub in the front left corner, two sealed 10" subs towards the front on the left and right, and two 10" ported subs in the back along the L and R walls. Each sub is near the wall but they are all different distances from the corners.
The response of each of these subs is different, and the locations are different, and they even are adjusted somewhat differently. The Talon is powered and so its independent. The left two are on one Dayton amp, the right two on another. Left and right are close but not identical in level. Or phase. All this asymmetry would be a nightmare for the mains, but is actually what you want with subs. All the slightly different responses produce different modes, in different places, and at different levels.
Placement becomes a whole lot easier with more subs. With just one you have one or two nasty humps to figure out. With four each one plays at a lot lower level so the humps are much smaller, and you can put them just about anywhere you want. I tried a lot of different things because it mattered so much with just the one. But with five I find it hardly matters at all.
Hook em all up, you will see.