But even this Ralph is null and void also, when the equipment has regulated supplies, as many "directional fusers" claim differences in fuse direction on their preamps and source equipment with regulated supplies.
As for them blowing for no reason, if indeed they do cryo them, this "can" make the fuse element more fragile harder/stiffer and suspect to de-rating it’s amperage and hence (blow earlier), a bit the opposite to what happens to us the older we get.
This has been my experience too. Our MP-1 preamp is heavily regulated so that the drop out voltage (overhead) is around 100Volts on a 117VAC line- so it can sag quite a lot without any change in the preamp's performance. And while we can easily measure a voltage drop across the fuseholder, no amount of changing the fuse has any effect on the preamp at all (and for the same reason, its very immune to power cord changes too).
But if you have an unregulated power supply as seen in most amplifiers, the fuse is probably going to have some sort of audible effect.