Can an “audiophile” ever be satisfied with a system?

Dittos to millercarbon. And others. Satisfaction isn't the goal for some of us. If I'm satisfied with the sound I might say to myself "fascinating," and then try the next interesting idea that comes along and that I can afford to implement. I still enjoy music quite a bit even when my system is configured in ways I'm not satisfied with, so the musical enjoyment remains consistent. 

“Can an “audiophile” ever be satisfied with a system?“

Absolutely! Until they’re not.

The Forum has been a real eye opener to many issues around my system and hobby. I never thought a I would not miss my SET before I moved to Atma-Sphere. And now I have a global view on my LP content.
For years, I winnowed down my large CD collection to about 100 that I always enjoy. I have them in three folders next to my office headphone system and love to listen when I am doing biz. I do listen to several over and over.
I've only fairly recently gotten serious about vinyl. I actually have already started sorting out the best LPs. It looks like I will do the same as my CDs with my hundreds of LPs.
Like I have said, when it comes to being satisfied with my system it is really all about 1. Content 2. Content and 3. Content.
Content for contentment!

I’ve realized for me it’s not really about being satisfied, as the urge to “try something new”

recently, I’ve learned cartridge swaps can accomplish that too.  I’ve been playing with some more budget carts like a retipped dl-103 and a sumiko blue point, and even if they aren’t as “good” as what they replaced, there’s enough different and interesting that it has scratched that certain itch to try something new. 

50 years on and a great sounding system (acc to others) and my answer is NO.

That particular joy of having arrived never lasts more than a few days/weeks.  My own personal record, from memory, is around 2 weeks.

some friends have average to lousy systems but man do they enjoy the music.  These are the blessed - they get it even if it's being filtered by an old sock. 

Thank goodness I'm not blessed!! Chasing excellence is the very essence of the human spirit.