I own the 5.3s and if you have at least a medium sized room and flexibility to place the speakers at least 3-4 ft from the back wall you might want to go that route to avoid dealing with a sub. Given a big enough room and proper placement they can really put a performance in your room.
If your room is on the small side and you need to keep the speakers within a foot or two of the rear wall you might have better luck with the sub/sat setup that will give you the flexibility to place and adjust the sub so it doesn't overload your room. The 5.3s really need room to breathe to be at their best(in my opinion) and they can get congested and boomy if they don't get the room they need. I'm actually thinking of selling my 5.3s(to trade up to 6.2s), so please feel free to email me if you think you might be interested. Hope this helped and best of luck.
Tim
If your room is on the small side and you need to keep the speakers within a foot or two of the rear wall you might have better luck with the sub/sat setup that will give you the flexibility to place and adjust the sub so it doesn't overload your room. The 5.3s really need room to breathe to be at their best(in my opinion) and they can get congested and boomy if they don't get the room they need. I'm actually thinking of selling my 5.3s(to trade up to 6.2s), so please feel free to email me if you think you might be interested. Hope this helped and best of luck.
Tim