Are Preamplifier’s Relevant Today or just a Hinderance with Digital Playback ?

I’m just curious,.I know from past experiences using a well designed preamplifier can and will make a difference however the computer audio crowd say different with the use of HQplayer with volume control including multiple filters and adjustments in OS mode using a preamplifier is blasphemy to some of them .

What’s your take on this subject? 
Thanks in advance.