My room is 15' x 22' with 18' ceilings. I have found that the choice of speaker is important; some speakers that I have tried "die" in the space while others excel.
Hopefully your ceilings are tall and flat. Mine are cathedrals and I'm convinced this is one of the worst configurations possible to manage for great audio. The RMAF website has videos of an interesting dialog on the subject with Jim Smith (Get Better Sound) and Charles Hanson (Ayre Acoustics).
I have had the opportunity (and luck) to listen to three different gears in different houses, comparing normal heigth ceilings with high ones, and I always liked them much more in the high ceiling houses. Treble and medium frequencies sound more natural to me in high ceilings houses.
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