Just wondering about speaker cables

No reason it shouldn’t work. I don’t think you want to pair two 9 gauge wires with each other. But hey! It might work...

It won't hurt anything. You're just increasing your wire gauge is all. But using two totally different cables won't give you the best of both, more like all of each:-)Give it a try and see what you think.

I am doing just that.
I have solid pure .9999 silver wire of various gauges that each gauge is in individually oversized teflon tubing and I also have copper foil. Both are connected to one set of amp/speaker terminals.
I used just the silver for a long time. A few months ago I bought the copper foil.

Each was good, but combined is was way better sonically in all areas that matter. I have recently tried this combo against some very pricey speaker cables and my Frankenstein arrangement is better.

ozzy

What you're describing is a fairly conventional set-up called shotgun, but with a significant variant.  Classic shotgun is two identical cables terminated at both ends with single set of spades or bananas to attach to amp and speaker.  Hence the name: double-barreled.

In a biwire situation, you could certainly have one type of cable on the speaker's tweeter connection, and another on its woofer.

You suggest, in a sense, combining these two set-ups.  As others have suggested, if could just as easily (or more easily) lead to messing up the sound as enhancing it.  Given that there are so many variables, only a trial would tell.

Or just find one cable that sounds good to you on all levels.  Lord knows there are enough out there to choose from, and it saves you from all the mixing/matching, trial and error, and potential added expense of going the other route.  Then again, whatever blows your skirt...