One would think after 117 years of evolution (1904, invention of the vacuum tube) and with only 4 other components involved (R, C, L, transformer) engineers would have reached the optimal configuration for a tube amplifier by now.Ya- you'd think. They've been making automatic transmissions for a while too, and yet they still fail in the middle of nowhere.
But there’s another ’science’ involved. It’s called Marketing ... the art of tempting people to spend top dollar.
There are actually innovations still occurring with vacuum tube amplifier tech (I can call out a couple of patent numbers if you like). Electrolytic caps keep getting better- and the better they get, the more effectively you can bypass a power supply. Plus we have computer modelling now so you can simulate and optimize circuits (including tube circuits) better than you could back in the days of slide rules.