As with all amps, power supplies are critical to best performance. My custom built 300B monoblocks each use power supply one generally sees in stereo amp. Larger, better ps equals more filtering-resolving powers, reserves of power-transient, micro and macro dynamics. Add in some silver internal wiring, hand output transformers, no soft romantic old fashioned 300B sound. Actually nearly the equal of my 845 in most of impact related sound qualities. Hard to believe when you compare 845, 300B power supplies. 300B power supply looks silly small in comparison to either of my 845's. Again, power tubes make large difference in SET, some romantic or old fashion sound, others modern sound, more linear.
I agree, SET will never be objectively best topology, just as any topology isn't. Each person has their own values as to what sounds best. Certainly, speaker choice is more limited vs higher power amps, although continually seeing introduction of more high efficiency speakers over time.