What is going to sound best depends on the synergies with your existing equipment.
My system is very revealing, IMO, and I found my Innuos Zen MkIII sounded much better with Roon running in experimental mode (one of the options they give you) than running Innuos Sense. It is a little glitchy running it from my iPad, occasionally loses the server for a minute and sometimes skips tracks, but the SQ has everything else beat - more detailed, more top end, more dynamic, more transparency, more presence.