There are 2 schools of thought on preamps: Preamp should "add to sound quality" and "preamp should be invisible".
Integrated tube amps usually are looking for the 2nd path to success. So if you're in that school of thought, integrated tube amps may be the way for you to go.
If you're in the first school, then separates may be the way to go.
That second school of thought is likely where we get “synergy” from.
(Bright horns, and warm amps, etc.)
Personally I want everything to be transparent and not spicing things up, and then using spoonfuls of yogurt and cucumber slices to cool it all down.
So we are back to wondering what speakers the OP wants to head towards in order to spice things towards making the “Synergy of the flaws” balance out.
(IMO)