The Nenuphar is a complete system, so it is hard to compare with a driver. So far, I haven't heard a single driver Lowther system I preferred to the Nenuphar, but, I haven't heard the Charney Audio system with the Lowther driver; I heard, and really liked their systems with AER and Voxativ drivers.
These days, single driver systems are doing so much more to overcome the disadvantages of a single driver, while retaining the advantages, such that they are contenders in the high end arena. For my taste, I like the two-way Nenuphar Basis and I still like really good horn-based systems more than single driver systems, but, I could live with a number of single driver systems I've heard.