Tweaks work well when they are used as tweaks. They are literally the icing on the cake, and for that approach to work (the icing to do its job), you need a darn good cake for starters. Icing will not do any good to an inedible cake...
That is: Put the system together right, then the tweaks will help to fine-tune the sound. The money spent on tweaks, when spent right, is about 1-2% of the total system cost. That is, the tweaks can add up to a serious amount when the total system budget is 1M$, but they should be modest in price for a 10K$ system, and should be next-to-free tweaks for a low budget system. Big mistake is to get the tweaks intended for a 1m$ system for a 1K$ total system... that's when snake-oil priests come and eat ya. ;
Now, cheaping out on a component and hoping for a tweak to replace a major 10K$ components with a basic one, adding a $300 tweak on it - that will not work at all.
Can't replace cake with icing....