The biggest issues I’ve found with PC’s are two fold:
1 - Galvanic isolation of USB. Some DAC’s have it built in, some do not. If you can’t solve this, go optical. This causes excess jitter and/or audible humm. In other words, a ground loop can show up digitally or in the analog stage with different symptoms.
2 - PC power supplies are terribly noisy.
A cheap, hospital grade USB isolator ($30) will fix 1, but with some DACs won’t work. I haven’t tried the iFi isolator with a power supply.
Keeping your PC, especially laptops, power supply out of your audio power supply chain is important. Don’t put it on the clean side of a power conditioner.
Ethernet however is inherently galvanically isolated. Again, if you are concerned, consider a hospital grade 4kV Ethernet isolator. Also useful for surge protection with long runs.
Interestingly, trying to keep your PC power supply isolated from your audio gear may in fact cause ground loops, since you want to plug the PC and audio gear into different branch circuits. This is why a good conditioner like Furman with LiFT/SMP can help.