Nice system. A great looking room.
Looking at your system my guess is the subwoofers are overloading the room with bass. I assume with the subs turned off you do not have the problem with the turntable? I would start here.
I am fortunate to have a large room. As @curiousjim points out, having wide spaces on both sides of the speakers can be good. You’ll probably need to heavily dampen the front and rear walls and the ceiling. It is worth a try… but I would first figure out how to stop the feedback.
I’ll give it some more thought. I am sure with the additional info you supplied, there will be some folks that will have helpful suggestions.