But I would just keep using the XLR balanced interconnects throughout especially if your gears are fully balanced design or true differential design internally. I don’t know if your Mac and Sim are true differential design or fully balanced design internally, but if they were, you will be better off using XLR cables throughout as it would sound better than using RCA single ended cables. it’s quieter (lower noise floor) when using XLR cables if your gears are fully balanced design or true differential design internally.
FYI, not all gears that provide XLR connectivity are fully balanced design or true differential design internally. Some are single ended design internally although they provide XLR connectivity (outputs & inputs). Marantz multi-channel power amps and their preamp surround processors are single ended design internally but they provide XLR balanced connectivity (inputs & outputs). So if your gears aren’t fully balanced design or true differential design design internally you can use RCA single ended interconnects and would sound the same whether you’re using RCA or XLR, or you would probably be better off using RCA in this case, unless if you're running long interconnects then use XLR cables.