I think it's more a matter of VERY attentive listening, and after really learning what you are listening for. I run one SB-3000 and two SB-2000 subs and subtle setting differences can also be very subtle to discern by ear as well, especially when buried under other music, usually louder.
I'll sometimes run just the SB-3000 and go between pre-sets to A-B the differences and learn a bit more while critically listening (which is not too often these days... :-)
I use measurements and feel they are very important in getting the best clean match and overall sound. A DSPeaker Anti-Mode 2.0 tames the room and speaker bass and the subs are dialed in later for a flat, measured in-room response.