I have had all-Ayre electronics at times (mostly early on in my audiophile journey), and systems mixing components, including an Aesthetix Janus Signature preamp now in my primary system, with an Ayre disc player fronting it (along with an SME turntable) and a VX-5 amp. I really like the Aesthetix/Ayre mix in my system, particularly with the preamp re-tubed with VTS offerings, and with more revealing speakers like Thiels and Vivids.
I've used Thiel 2.3s in the past (took a long time to tame its high end when I had an Ayre preamp in the mix as well as amp); Monitor Audio speakers in my secondary system in recent years; Vivid B1s currently in my primary system; and the likelihood of getting Vandersteens in a CT iteration for my (hopefully final) primary system speakers. .