Yep. Usually the way to do it is to keep the speakers and amps the same, but switch preamps.
So you would run pre-out L and R from an AVR or pure processor, to your 2 channel preamp/integrated which has a bypass input and switch.
Personally I do this with Anthem MRX 520 and Luxman 507. Works fine except for all the remotes, which I am about to fix. Hehehhe.