Lloydc,
Theoretically that is true, but for the lowest audible frequencies that a sub would deliver in an already mostly full range system, how much it matters practically is debatable I think.
That using more subs enables smoother bass response throughout the room is a significant advantage nonetheless, if that matters. 4 is even better than 2 and 2 is better than one and the results in most cases should be clearly audible. Audiokinesis is the vendor in these parts who designs some of his speakers in a modular manner that allow for this by design up front.