The 845 is not happy at 500 volts. It is a (low-power) transmitter tube, and is designed to work from 800 volts (minimum) to well over 1000 volts.
Once you go over 500 volts, construction, and the parts required, are a whole different world. It requires ham-radio transmitter technique. Parts are air-spaced, wires DO NOT lay on each other, circuit boards are out of the question, and special-order high-voltage power and output transformers are required. Electrolytic caps have a hard upper limit of 550 volts, and 1 kV film caps are industrial parts, not audiophile specials. In short everything is different. Consult a 1950’s American Radio Relay League (ARRL) handbook to see what safe construction technique looks like. It is nothing like audiophile practice.
Sure, the builder can ignore safe construction technique and build it the regular way, but that’s a very serious safety and fire hazard. You do NOT want an amplifier exploding and then catching on fire. Transmitter technique takes us out of consumer electronics and into the realm of professional high-voltage equipment ... interlocked chassis doors, special start-up techniques, status lights, etc.
Yes, I see audio equipment at shows with hard-core Eimac transmitter tubes that light up the room. I would never allow anything like that in my house, unless it was in an outbuilding. The companies that build these high-voltage amplifiers have no track record of building ham or pro radio gear ... they’re just winging it, despite the curved glasswork and the pretty CNC chassis.
By contrast, the 300B lives in KT88 territory, with similar voltages and operating currents. Standard hifi building technique, but still not a plaything. The voltages in the B+ caps are quite lethal, so no poking fingers where they don’t belong.