What speaker could safely be ordered without hearing it first?

I've heard the Joseph Audio speakers, not in my own room, but enough times that it would be an easy recommendation to buy without an audition. 

"How "safe" do you want to be?

Personally, I'd never buy any speaker I couldn’t first audition in my room.

Your money. 

Your ears. "

I'm pretty sure this rarely happens. Its a great idea, but I can't imagine many dealers are going to let you take expensive speakers home, unbox them, audition them,re-box them and then bring them back. They may sell them too you, and let you bring them back with a restocking fee.

I think if you read enough. You can pick a brand/model that works well with your existing gear. I always stay with well known brands that have good resale value.

I bought my last last speakers unheard and they are the best I have owned. Trust the measurements, they will point you in the right direction.  

Within the confines of room and amplifier:

Agree with--

Joseph Audio

Monitor Audio

Fritz

Magico

Magnepan

Possibly agree with Yamaha NS5000

And would add--

JBL 4367

Revel PerformaBe

Kef Reference

Neumann

Harbeth P3ESR

I always try to audition, preferably at home but I broke that rule when I ordered my Omega Super Alnico Monitor.   They have a 30 day return privilege , but hopefully i will really like them.